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Feet

By the time you're 40, you've put a lot of wear and tear on a structure consisting of 26 bones, 33 joints, 107 ligaments, and 19 muscles and tendons. Your feet widen as you age, so get shoes that fit, and replace running shoes regularly, even if they don't look worn: Every 350 to 450 miles for runners, every six to nine months for walkers.